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Ulixacaltamide

CAT: 0804-HY-120546-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120546-01Size:5 mg
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Description
Ulixacaltamide (Z944) is an orally available T-type calcium channel antagonist that can slow the progression of epilepsy. Ulixacaltamide effectively reduces tremor in a normal alkaline tremor animal model. Ulixacaltamide reverses thermal hyperalgesia and mediates pain relief[1][2][3][4].
CAS Number
1199236-64-0
Product Name Alternative
Z944; PRAX-944
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ulixacaltamide.html
Concentration
10mM
Purity
98.73
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC(F)=CC(Cl)=C1)NCC2CCN(CC2)CC(NC(C)(C)C)=O
Molecular Formula
C19H27ClFN3O2
Molecular Weight
383.89
References & Citations
[1]Marks WN, et al. The T-type calcium channel antagonist Z944 rescues impairments in crossmodal and visual recognition memory in Genetic Absence Epilepsy Rats from Strasbourg. Neurobiol Dis. 2016 Oct;94:106-15. |[2]Casillas-Espinosa P M, et al. Z944, a novel selective T-type calcium channel antagonist delays the progression of seizures in the amygdala kindling model[J]. PLoS One, 2015, 10 (8) : e0130012.|[3]Scott L, et al. Translational pharmacology of PRAX‐944, a novel T‐type calcium channel blocker in development for the treatment of essential tremor[J]. Movement Disorders, 2022, 37 (6) : 1193-1201.|[4]Antunes F T T, et al. Effect of ABT-639 on Cav3. 2 channel activity and its analgesic actions in mouse models of inflammatory and neuropathic pain[J]. European Journal of Pharmacology, 2024, 967: 176416.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
T-type calcium channel

Alternative Products

CatalogName
GTR19241954-01Ulixacaltamide HCl

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