BAR501

• UNSPSC Description:

  BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM.

• Target Antigen:

  G protein-coupled Bile Acid Receptor 1

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/BAR501.html

• Purity:

  98.0

• Solubility:

  DMSO : ≥ 50 mg/mL|Ethanol : 120 mg/mL (ultrasonic)

• Smiles:

  C[C@H](CCCO)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C

• Molecular Weight:

  406.64

• References & Citations:

  [1]Renga B, et al. Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1. PLoS One. 2015 Nov 5;10(11):e0141082.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1632118-69-4