Hsp90-Cdc37-IN-3

Hsp90-Cdc37-IN-3

• CAS Number: 2361009-68-7
• UNSPSC Description: Hsp90-Cdc37-IN-3 (Compound 9) is a novel celastrol?imidazole derivative with anticancer activity. Hsp90-Cdc37-IN-3 inhibits Hsp90?Cdc37 by covalent-binding, and induces apoptosis[1].
• Target Antigen: Apoptosis; HSP
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/hsp90-cdc37-in-3.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C1C(O)=C(C2=CC=C3[C@](C)([C@]4(CC[C@]3(C2=C1)C)C)CC[C@@]5([C@@]4([H])C[C@](C(OCCCN6C(Cl)=NC([N+]([O-])=O)=C6)=O)(CC5)C)C)C
• Molecular Weight: 638.19
• References & Citations: [1]Na Li, et al. Discovery of Novel Celastrol-Imidazole Derivatives with Anticancer Activity In Vitro and In Vivo. J Med Chem. 2022 Mar 24;65(6):4578-4589.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported