Dehydroabietic acid

• Description:

  Dehydroabietic acid is a diterpene resin acid that can be isolated from Pinus and Picea. Dehydroabietic acid has anti-bacterial, anti-fungal, anti-inflammatory, and anticancer activities. Dehydroabietic acid is a dual PPAR-α/γ agonist and PPAR-γ partial agonist, which can attenuate insulin resistance (IR) and hepatic steatosis induced by HFD-consumption in mice[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H400, H410

• Target:

  Antibiotic; Bacterial; Fungal; PPAR

• Type:

  Natural Products

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Cancer; Infection; Metabolic Disease; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/dehydroabietic-acid.html

• Purity:

  99.75

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C ([C@]1 (C) CCC[C@]2 (C) C3=C (CC[C@@]12[H]) C=C (C (C) C) C=C3) O

• Molecular Formula:

  C20H28O2

• Molecular Weight:

  300.44

• Precautions:

  H301, H400, H410

• References & Citations:

  [1]Kim E, et al. Dehydroabietic Acid Suppresses Inflammatory Response Via Suppression of Src-, Syk-, and TAK1-Mediated Pathways. Int J Mol Sci. 2019 Mar 29;20 (7) :1593. |[2]Xie Z, et al. Dehydroabietic acid alleviates high fat diet-induced insulin resistance and hepatic steatosis through dual activation of PPAR-γ and PPAR-α. Biomed Pharmacother. 2020 Jul;127:110155.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 4

• CAS Number:

  1740-19-8