Plasmepsin II FRET Substrate

• Description:

  Plasmepsin II FRET Substrate_x000D_ Catalog number: B2011261_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 1 mg_x000D_ Molecular Weight or Concentration: 1896.2 g/mol_x000D_ Supplied as: Lyophilized_x000D_ Applications: molecular tool for various biochemical applications_x000D_ Storage: -20 °C_x000D_ Keywords: Plasmepsin II FRET Substrate, Hemoglobin Fragment_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Liu J, Istvan ES, Goldberg DE. Hemoglobin-degrading plasmepsin II is active as a monomer J Biol Chem. 2006 Dec 15;281(50):38682-8._x000D_ 2: Mohapatra SC, Tiwari HK, Singla M, Rathi B, Sharma A, Mahiya K, Kumar M, Sinha S, Chauhan SS. Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum J Biol Inorg Chem. 2010 Mar;15(3):373-85._x000D_ 3: Silva AM, Lee AY, Gulnik SV, Maier P, Collins J, Bhat TN, Collins PJ, Cachau RE, Luker KE, Gluzman IY, Francis SE, Oksman A, Goldberg DE, Erickson JW. Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10034-9._x000D_ 4: Dan N, Bhakat S. New paradigm of an old target: an update on structural biology and current progress in drug design towards plasmepsin II Eur J Med Chem. 2015 May 5;95:324-48._x000D_ 5: Foguim Tsombeng F, Gendrot M, Robert MG, Madamet M, Pradines B. Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa? Malar J. 2019 Aug 23;18(1):285._x000D_ 6: Corminboeuf O, Dunet G, Hafsi M, Grimont J, Grisostomi C, Meyer S, Binkert C, Bur D, Jones A, Prade L, Brun R, Boss C. Inhibitors of Plasmepsin II-potential antimalarial agents Bioorg Med Chem Lett. 2006 Dec 15;16(24):6194-9._x000D_ 7: Song Y, Jin H, Liu X, Zhu L, Huang J, Li H. Discovery of non-peptide inhibitors of Plasmepsin II by structure-based virtual screening Bioorg Med Chem Lett. 2013 Apr 1;23(7):2078-82._x000D_ 8: Qidwai T, Yadav DK, Khan F, Dhawan S, Bhakuni RS. QSAR, docking and ADMET studies of artemisinin derivatives for antimalarial activity targeting plasmepsin II, a hemoglobin-degrading enzyme from P. falciparum Curr Pharm Des. 2012;18(37):6133-54._x000D_ 9: Ersmark K, Samuelsson B, Hallberg A. Plasmepsins as potential targets for new antimalarial therapy Med Res Rev. 2006 Sep;26(5):626-66._x000D_ 10: Bjelic S, Nervall M, Gutiérrez-de-Terán H, Ersmark K, Hallberg A, Aqvist J. Computational inhibitor design against malaria plasmepsins Cell Mol Life Sci. 2007 Sep;64(17):2285-305. _x000D_ _x000D_ Products Related to Plasmepsin II FRET Substrate can be found at Substrates

• Short Description:

  Catalog Number: B2011261 (1 mg)_x000D_ Plasmepsin II FRET Substrate is a high quality synthetic peptide containing the cleavage site by plasmepsin II within hemoglobin. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5