Recombinant UBE2L6 Protein

• Description:

  Recombinant UBE2L6 Protein_x000D_ Catalog number: B2017683_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 19.93 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: Ubiquitin Conjugating Enzyme E2 L6, RIG-B, UBCH8, RIG-B, ubch8_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Durfee LA, Kelley ML, Huibregtse JM. The basis for selective E1-E2 interactions in the ISG15 conjugation system J Biol Chem. 2008 Aug 29;283(35):23895-902._x000D_ 2: Takeuchi T, Iwahara S, Saeki Y, Sasajima H, Yokosawa H. Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme J Biochem. 2005 Dec;138(6):711-9._x000D_ 3: Kuser-Abali G, Zhang Y, Szeto P, Zhao P, Masoumi-Moghaddam S, Fedele CG, Leece I, Huang C, Cheung JG, Ameratunga M, Noguchi F, Andrews MC, Wong NC, Schittenhelm RB, Shackleton M. UHRF1/UBE2L6/UBR4-mediated ubiquitination regulates EZH2 abundance and thereby melanocytic differentiation phenotypes in melanoma Oncogene. 2023 Apr;42(17):1360-1373._x000D_ 4: Afsar M, Liu G, Jia L, Ruben EA, Nayak D, Sayyad Z, Bury PDS, Cano KE, Nayak A, Zhao XR, Shukla A, Sung P, Wasmuth EV, Gack MU, Olsen SK. Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer Nat Commun. 2023 Aug 8;14(1):4786._x000D_ 5: Orfali N, Shan-Krauer D, O'Donovan TR, Mongan NP, Gudas LJ, Cahill MR, Tschan MP, McKenna SL. Inhibition of UBE2L6 attenuates ISGylation and impedes ATRA-induced differentiation of leukemic cells Mol Oncol. 2020 Jun;14(6):1297-1309._x000D_ 6: Murakami M, Izumi H, Kurita T, Koi C, Morimoto Y, Yoshino K. UBE2L6 is Involved in Cisplatin Resistance by Regulating the Transcription of ABCB6 Anticancer Agents Med Chem. 2020;20(12):1487-1496._x000D_ 7: Wei W, Li Y, Li Y, Li D. Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis J Pharmacol Sci. 2021 Apr;145(4):327-334._x000D_ 8: Gao J, Li C, Li W, Chen H, Fu Y, Yi Z. Increased UBE2L6 regulated by type 1 interferon as potential marker in TB J Cell Mol Med. 2021 Dec;25(24):11232-11243._x000D_ 9: Shibahara M, Kurita T, Murakami M, Harada H, Koi C, Izumi H, Yoshino K. Association of UBE2L6 and ABCB6 Expression With Platinum Resistance in Serous Ovarian Carcinoma Anticancer Res. 2023 Aug;43(8):3787-3792._x000D_ 10: Li Y, Dong X, He W, Quan H, Chen K, Cen C, Wei W. Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation Obes Facts. 2024;17(1):24-36. _x000D_ _x000D_ Products Related to Recombinant UBE2L6 Protein can be found at Proteins

• Short Description:

  Catalog Number: B2017683 (50 µg)_x000D_ Recombinant UBE2L6 protein is a version of the UBE2L6 protein produced using recombinant DNA technology. UBE2L6 is an enzyme involved in the ubiquitination process, essential for regulating protein degradation and turnover in cells. It is utilized in research to explore its function and protein interactions. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3