CA-074 Me

CA-074 Me Catalog number: MDP0691 CAS Number: N/A Sequence: [(2S,3S)-3-Propylcarbamoyloxirane-2-carbonyl]-L-isoleucyl-L-proline methyl ester Amount: 1 mg Molecular Weight: 397.2 g/mol Supplied as: Powder Applications: molecular tool for various biochemical applications Storage: -20 °C WARNING: For in vitro Research Use Only. NOT for use on humans or animals. Grade: Biotechnology grade. All products are highly pure. References: 1: He X, Fan X, Bai B, Lu N, Zhang S, Zhang L. Pyroptosis is a critical immune-inflammatory response involved in atherosclerosis Pharmacol Res. 2021 Mar;165:105447. 2: Yoon MC, Christy MP, Phan VV, Gerwick WH, Hook G, O'Donoghue AJ, Hook V. Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B Biochemistry. 2022 Feb 15;61(4):228-238. 3: Guiney SJ, Adlard PA, Lei P, Mawal CH, Bush AI, Finkelstein DI, Ayton S. Fibrillar α-synuclein toxicity depends on functional lysosomes J Biol Chem. 2020 Dec 18;295(51):17497-17513. 4: Montaser M, Lalmanach G, Mach L. CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells Biol Chem. 2002 Jul-Aug;383(7-8):1305-8. 5: Lowry JR, Klegeris A. Emerging roles of microglial cathepsins in neurodegenerative disease Brain Res Bull. 2018 May;139:144-156. 6: Mihalik R, Imre G, Petak I, Szende B, Kopper L. Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown Cell Death Differ. 2004 Dec;11(12):1357-60. 7: Ansari MA, Nadeem A, Alshammari MA, Attia SM, Bakheet SA, Khan MR, Albekairi TH, Alasmari AF, Alhosaini K, Alqahtani F, Al-Mazroua HA, Ahmad SF. Cathepsin B inhibitor alleviates Th1, Th17, and Th22 transcription factor signaling dysregulation in experimental autoimmune encephalomyelitis Exp Neurol. 2022 May;351:113997. 8: Dana D, Pathak SK. A Review of Small Molecule Inhibitors and Functional Probes of Human Cathepsin L Molecules. 2020 Feb 6;25(3):698. 9: Brojatsch J, Lima H Jr, Palliser D, Jacobson LS, Muehlbauer SM, Furtado R, Goldman DL, Lisanti MP, Chandran K. Distinct cathepsins control necrotic cell death mediated by pyroptosis inducers and lysosome-destabilizing agents Cell Cycle. 2015;14(7):964-72. 10: Sharma A, Swetha R, Bajad NG, Ganeshpurkar A, Singh R, Kumar A, Singh SK. Cathepsin B-A Neuronal Death Mediator in Alzheimer's Disease Leading to Neurodegeneration Mini Rev Med Chem. 2022;22(15):2012-2023.
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Catalog Number: MDP0691 (1 mg)

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