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Benzenesulphonamide

CAT: 0804-HY-101087-01Size: 5 gDry Ice: NoHazardous: No
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CAT#:0804-HY-101087-01Size:5 g
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Description
Benzenesulphonamide (Compound 1) is a carbonic anhydrase inhibitor. Benzenesulphonamide exhibits CA II inhibitory activity. Benzenesulphonamide reduces ROS and improves the gene expression of amyloid-β40 and 42. Benzenesulphonamide is beneficial for Alzheimer's disease. Benzenesulphonamide derivatives have anticancer, anti-inflammatory, and anticonvulsant activities. Benzenesulphonamide can be used in the research of Alzheimer's disease, epilepsy, inflammatory diseases, leukemia, melanoma, lung cancer, and colon cancer[1][2][3][4][5].
CAS Number
98-10-2
UNSPSC
12352005
Hazard Statement
H302
Target
Amyloid-β; Carbonic Anhydrase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/benzenesulphonamide.html
Concentration
10mM
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=CC=C1)(N)=O
Molecular Formula
C6H7NO2S
Molecular Weight
157.19
Precautions
H302
References & Citations
[1]Thakur A, et al. QSAR study on benzenesulphonamide carbonic anhydrase inhibitors: topological approach using Balaban index. Bioorg Med Chem. 2004 Feb 15;12 (4) :789-93. |[2]Hesar Shourkabi M, et al. Benzenesulfonamide as a novel, pharmaceutical small molecule inhibitor on Aβ gene expression and oxidative stress in Alzheimer's Wistar rats. Biochem Biophys Res Commun. 2023 Sep 24;674:154-161.|[3]Bashir R, et al. Synthesis of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide as anticancer and anti-inflammatory agents. Bioorg Med Chem Lett. 2011 Jul 15;21 (14) :4301-5. |[4]Nissan YM, et al. New benzenesulfonamide scaffold-based cytotoxic agents: Design, synthesis, cell viability, apoptotic activity and radioactive tracing studies. Bioorg Chem. 2020 Mar;96:103577. |[5]Wang Z, et al. Synthesis and Pharmacological Evaluation of Novel Benzenesulfonamide Derivatives as Potential Anticonvulsant Agents. Molecules. 2015 Sep 23;20 (9) :17585-600.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II

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FB34348Benzenesulphonamide
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