Venlafaxine-d6 (hydrochloride)

Venlafaxine-d6 (hydrochloride)

• CAS Number: 1062606-12-5
• UNSPSC Description: Venlafaxine-d6 (hydrochloride) is the deuterium labeled Venlafaxine hydrochloride. Venlafaxine hydrochloride (Wy 45030 hydrochloride) is an orally active, potent serotonin (5-HT)/norepinephrine (NE) reuptake dual inhibitor. Venlafaxine is an antidepressant[1].
• Target Antigen: Serotonin Transporter
• Type: Isotope-Labeled Compounds
• Related Pathways: Neuronal Signaling
• Field of Research: Neurological Disease
• Purity: 98.18
• Solubility: DMSO : 10 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: OC1(C(C2=CC=C(OC)C=C2)CN(C([2H])([2H])[2H])C([2H])([2H])[2H])CCCCC1.[H]Cl
• Molecular Weight: 319.90
• References & Citations: [2]Bymaster FP, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.|[3]Goeringer KE, et al. Postmortem tissue concentrations of venlafaxine. Forensic Sci Int. 2001 Sep 15;121(1-2):70-5.|[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported