BP13944

CAT: 0804-HY-136797Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-136797Size:1 Each

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Description

BP13944 is a potential small molecule inhibitor discovered by high-throughput screening. It can effectively inhibit the expression of dengue virus (DENV) replicons with an EC50 value of 1.03±0.09 μM. BP13944 can inhibit the replication or viral RNA synthesis of all four serotypes of DENV, but is ineffective against Japanese encephalitis virus. BP13944 may target the DENV NS3 protease, and the E66G amino acid substitution in the NS3 protease region will cause the virus to become resistant to BP13944. BP13944 has no obvious cytotoxicity. As there is currently no effective dengue vaccine and treatment, BP13944, as an effective small molecule inhibitor, may become a potential agent for the treatment of dengue in the future.

CAS Number

1622060-51-8

UNSPSC

12352211

Target

Dengue Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/bp13944.html

Smiles

CCCCCCCCCCCCCCCC[N+](CO)(CC)CO.[Br-]

Molecular Formula

C20H44BrNO2

Molecular Weight

410.47

References & Citations

[1]A Novel Dengue Virus Inhibitor, BP13944, Discovered by High-Throughput Screening with Dengue Virus Replicon Cells Selects for Resistance in the Viral NS2B/NS3 Protease

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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MBS5774906	BP13944

BP13944

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