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G907

CAT: 0804-HY-125176-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125176-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
G907 is a selective antagonist of ATP-binding cassette (ABC) transporter MsbA with anti-microbial activity. G907 inhibits E. coli MsbA with an IC50 value of 18 nM. G907 traps MsbA in an inward-facing, lipopolysaccharide-bound conformation by wedging into an architecturally conserved transmembrane pocket[1][2].
CAS Number
2244035-16-1
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/g907.html
Purity
98.06
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(O)/C=C/C1=C(C2CC2)C3=CC(OC(C4=C(C5CC5)C=CC=C4Cl)C)=CC=C3N=C1
Molecular Formula
C26H24ClNO3
Molecular Weight
433.93
References & Citations
[1]Ho H, et al. Structural basis for dual-mode inhibition of the ABC transporter MsbA. Nature. 2018 May;557 (7704) :196-201.|[2]Guo D, et al. Energetics of lipid transport by the ABC transporter MsbA is lipid dependent. Commun Biol. 2021 Dec 9;4 (1) :1379.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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