Deserpidine

• Description:

  Deserpidine (Harmonyl) is an alkaloid isolated from the root of Rauwolfia canescens related to Reserpine. Deserpidine is used as an antihypertensive agent and a tranquilizer. Deserpidine is a competitive angiotensin converting enzyme (ACE) inhibitor. Deserpidine also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex[1][2][3].

• Product Name Alternative:

  Harmonyl

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Angiotensin-converting Enzyme (ACE)

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Neurological Disease; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/deserpidine.html

• Purity:

  98.82

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  COC ([C@H]1[C@@]2 ([H]) C[C@]3 ([H]) C4=C (CCN3C[C@@]2 ([H]) C[C@@H] (OC (C5=CC (OC) =C (OC) C (OC) =C5) =O) [C@@H]1OC) C6=CC=CC=C6N4) =O

• Molecular Formula:

  C32H38N2O8

• Molecular Weight:

  578.65

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Varchi G, et al. Synthesis of deserpidine from reserpine. J Nat Prod. 2005 Nov;68 (11) :1629-31.|[2]Zhang H, et al. Liquid chromatography/tandem mass spectrometry method for the quantification of deserpidine in human plasma: Application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877 (27) :3221-5.|[3]Fulton SC, et al. Comparison of the effectiveness of deserpidine, reserpine, and alpha-methyltyrosine on brain biogenic amines. Fed Proc. 1976 Dec;35 (14) :2558-62.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Launched

• CAS Number:

  131-01-1