Nitecapone

• Description :

  Nitecapone (OR-462) is an orally active and short-acting catechol-O-methyltransferase (COMT) inhibitor with gastroprotective and antioxidant properties. Nitecapone (OR-462) scavenges reactive oxygen and nitric radicals and prevents lipid peroxidation[1][2][3].

• CAS Number :

  [116313-94-1]

• Product Name Alternative :

  OR-462

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  COMT

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/nitecapone.html

• Concentration :

  10mM

• Purity :

  99.32

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  CC(/C(C(C)=O)=C/C1=CC([N+]([O-])=O)=C(O)C(O)=C1)=O

• Molecular Formula :

  C12H11NO6

• Molecular Weight :

  265.22

• Precautions :

  H301

• References & Citations :

  [1]Y J Suzuki, et al. Antioxidant properties of nitecapone (OR-462) . Free Radic Biol Med. 1992 Nov;13 (5) :517-25.|[2]Marcocci L, et al. Nitecapone: a nitric oxide radical scavenger. Biochemistry and Molecular Biology International, 01 Oct 1994, 34 (3) :531-541.|[3]Oleg Kambur, et al. Nitecapone reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats. Eur J Pain. 2011 Aug;15 (7) :732-40.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2