Thalidomide-piperidine-C2-piperazine-Boc

• UNSPSC Description:

  Thalidomide-piperidine-C2-piperazine-Boc is an E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-130639) based cereblon ligand and a linker used in PROTAC technology. Thalidomide-piperidine-C2-piperazine-Boc can be used for synthesis of PROTACs[1].

• Target Antigen:

  E3 Ligase Ligand-Linker Conjugates

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/thalidomide-piperidine-c2-piperazine-boc.html

• Smiles:

  O=C(N(C1CCC(NC1=O)=O)C2=O)C(C2=C3)=CC=C3N4CCC(CCN5CCN(C(OC(C)(C)C)=O)CC5)CC4

• Molecular Weight:

  553.65

• References & Citations:

  [1]Danli Zhou, et al. Discovery of Potent and Highly Selective Interleukin-2-Inducible T-Cell Kinase Degraders with In Vivo Activity. J Med Chem. 2023 Apr 13;66(7):4979-4998.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported