Ethosuximide

• Description :

  Ethosuximide, a widely prescribed anti-epileptic agent, improves the phenotypes of multiple neurodegenerative disease models and blocks the low voltage activated T-type calcium channel.

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Calcium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease; Cancer

• Assay Protocol :

  https://www.medchemexpress.com/Ethosuximide.html

• Concentration :

  10mM

• Purity :

  99.35

• Solubility :

  DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C(C)(CC)C1)NC1=O

• Molecular Formula :

  C7H11NO2

• Molecular Weight :

  141.17

• Precautions :

  H302

• References & Citations :

  [1]Chen X, et al. Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. Mol Neurodegener. 2015 Sep 29;10:51.|[2]Sondossi K, et al. Analysis of the antiepileptic, ethosuximide impacts on neurogenesis of rat forebrain stem cells. Fundam Clin Pharmacol. 2014 Oct;28 (5) :512-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  T-type calcium channel

• CAS Number :

  [77-67-8]