WL12

• Description :

  WL12 is a specifically targeting programmed death ligand 1 (PD-L1) binding peptide. WL12 can be radiolabeled by different radionuclides, generating radiotracers, which can assess the tumor PD-L1 expression[1].

• UNSPSC :

  12352209

• Target :

  PD-1/PD-L1; Radionuclide-Drug Conjugates (RDCs)

• Type :

  Peptides

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Immunology/Inflammation

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/wl12.html

• Purity :

  99.99

• Solubility :

  H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  C(C=1C=2C(N(C)C1)=CC=CC2)[C@H]3C(=O)N(C)[C@@H](CCCC)C(=O)N(C)[C@@H](CCCC)C(=O)N[C@@H](CCCN)C(=O)N[C@H](C(NCC(N)=O)=O)CSCC(=O)N[C@@H](CC4=CC=C(O)C=C4)C(=O)N(C)[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N5[C@](C(=O)N[C@@H](CC6=CN=CN6)C(=O)N[C@@H](CC(C)C)C(=O)N7[C@](C(=O)N[C@@H](CC=8C=9C(NC8)=CC=CC9)C(=O)N[C@@H](CO)C(=O)N3)(C[C@@H](O)C7)[H])(CCC5)[H]

• Molecular Formula :

  C91H128N22O20S

• Molecular Weight :

  1882.19

• References & Citations :

  [1]Jiang J, et al. Noninvasive evaluation of PD-L1 expression using Copper 64 labeled peptide WL12 by micro-PET imaging in Chinese hamster ovary cell tumor model. Bioorg Med Chem Lett. 2021 May 15;40:127901.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  RDC Peptide

• CAS Number :

  [1886057-64-2]