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Sominone

CAT: 0804-HY-N10889-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N10889-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sominone is the active metabolite of Withanoside IV. Sominone enhances neuronal morphological plasticity by activating the RET pathway. Sominone can also induce axon/dendrite regeneration and synaptic reconstruction, thereby improving spatial memory. Sominone can be used in the research of neurodegenerative diseases such as Alzheimer's disease[1][2][3].
CAS Number
98569-64-3
UNSPSC
12352005
Target
Drug Metabolite; RET
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sominone.html
Purity
95.86
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](C[C@@H]2O)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@@H]([C@@]5([H])CC(C)=C(C(O5)=O)CO)C)C
Molecular Formula
C28H42O5
Molecular Weight
458.63
References & Citations
[1]Kuboyama T, et al. Withanoside IV and its active metabolite, sominone, attenuate Abeta (25-35) -induced neurodegeneration. Eur J Neurosci. 2006 Mar;23 (6) :1417-26.|[2]Tohda C, et al. Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET. Br J Pharmacol. 2009 Aug;157 (8) :1427-40.|[3]Joyashiki E, et al. Sominone improves memory impairments and increases axonal density in Alzheimer's disease model mice, 5XFAD. Int J Neurosci. 2011 Apr;121 (4) :181-90.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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