Emlenoflast

Emlenoflast

• Description :

  Emlenoflast (MCC7840), a sulfonylurea, is a potent and selective inhibitor of NLRP3 inflammasome, with an IC50 of [1][2].

• Product Name Alternative :

  MCC7840

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  NOD-like Receptor (NLR)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/mcc7840.html

• Purity :

  98.19

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=S(C1=NN(C(C)C)C=C1)(NC(NC2=C3CCCC3=CC4=C2CCC4)=O)=O

• Molecular Formula :

  C19H24N4O3S

• Molecular Weight :

  388.48

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]El-Sharkawy LY, et, al. Inhibiting the NLRP3 Inflammasome. Molecules. 2020 Nov 25;25 (23) :5533.|[2]O'neill L, et, al. Sulfonylureas and related compounds and use of same. WO2016131098A1.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NLRP3

• CAS Number :

  [1995067-59-8]