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CMLD010509

CAT: 0804-HY-119271-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119271-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CMLD010509 (SDS-1-021) is a highly specific inhibitor of the oncogenic translation program supporting multiple myeloma (MM) -including key oncoproteins such as MYC, MDM2, CCND1, MAF, and MCL-1. CMLD010509 (SDS-1-021) shows an IC50 below 10 nM for most MM cell lines and induces apoptosis. CMLD010509 (SDS-1-021) is a potent and selective translation inhibitor through an eIF4E phosphorylation-independent mechanism[1].
CAS Number
256497-58-2
Product Name Alternative
SDS-1-021
UNSPSC
12352005
Target
Apoptosis; c-Myc
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cmld010509.html
Purity
99.11
Solubility
DMSO : 60 mg/mL (ultrasonic)
Smiles
O=C([C@H]([C@H]1C2=CC=CC=C2)[C@@H](O)[C@]3(O)[C@@]1(C4=CC=C(Br)C=C4)OC5=CC(OC)=CC(OC)=C35)NOC
Molecular Formula
C27H26BrNO7
Molecular Weight
556.40
References & Citations
[1]Manier S, et al. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Sci Transl Med. 2017 May 10;9 (389) . pii: eaal2668.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19206191-01CMLD010509

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