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Rooperol

CAT: 0804-HY-119666Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-119666Size:1 Each
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Description
Rooperol is a norlignan analog with antitumor, anti-inflammatory, and antioxidant activities. Rooperol induces apoptosis in CSCs through a mitochondrial-induced increase in ROS and a p53-dependent pathway, while also downregulating the expression of key stem cell regulatory factors, such as Oct4, Nanog, and Sox2, ultimately exerting its anticancer effects[1][2][3][4].
CAS Number
83644-00-2
UNSPSC
12352005
Target
Apoptosis; MDM-2/p53; Oct3/4; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/rooperol.html
Smiles
OC1=CC=C(C=C1O)/C=C/CC#CC2=CC=C(C(O)=C2)O
Molecular Formula
C17H14O4
Molecular Weight
282.29
References & Citations
[1]Boukes G J, et al. Rooperol as an antioxidant and its role in the innate immune system: An in vitro study[J]. Journal of ethnopharmacology, 2012, 144 (3) : 692-699.|[2]Kabanda M M. Antioxidant activity of rooperol investigated through Cu (I and II) chelation ability and the hydrogen transfer mechanism: a DFT study[J]. Chemical research in toxicology, 2012, 25 (10) : 2153-2166.|[3]Guzdek A, et al. Rooperol, an inhibitor of cytokine synthesis, decreases the respiratory burst in human and rat leukocytes and macrophages[J]. Mediators of Inflammation, 1997, 6 (1) : 53-57.|[4]Ali Azouaou S, et al. Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells[J]. Investigational New Drugs, 2015, 33: 64-74.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
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