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Cenerimod

CAT: 0804-HY-17606-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17606-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cenerimod (ACT-334441) is a potent, selective and orally active S1P1 receptor modulator, with an EC50 of 1 nM. Cenerimod shows more than 36 fold selctivity for hS1P1 over hS1P2, hS1P3, hS1P4, and hS1P5 receptor subtypes (EC50s=>10000, 228, 2134, and 36 nM, respectively) . Cenerimod can attenuate murine experimental autoimmune encephalomyelitis (EAE) and murine sclerodermatous[1][2].
CAS Number
1262414-04-9
Product Name Alternative
ACT-334441
UNSPSC
12352005
Hazard Statement
H300, H361, H373
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Cenerimod.html
Purity
99.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC[C@H](O)COC1=C(C)C=C(C2=NOC(C3=CC(C4CCCC4)=NC(OC)=C3)=N2)C=C1CC
Molecular Formula
C25H31N3O5
Molecular Weight
453.53
Precautions
H300, H361, H373
References & Citations
[1]Piali L, et, al. Cenerimod, a novel selective S1P 1 receptor modulator with unique signaling properties. Pharmacol Res Perspect. 2017 Dec;5 (6) :e00370.|[2]Kano M, et, al. Attenuation of murine sclerodermatous models by the selective S1P 1 receptor modulator cenerimod. Sci Rep. 2019 Jan 24;9 (1) :658.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
S1PR1; S1PR4; S1PR5

Alternative Products

CatalogName
BA5465-10Cenerimod
A20913-100Cenerimod 100mg
A20913-10Cenerimod 10mg
A20913-5Cenerimod 5mg
A20913-50Cenerimod 50mg
A20913-25Cenerimod 25mg
A20913-2Cenerimod 2mg
A20913-10mM-DCenerimod 10mM * 1mL in DMSO

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