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Cymarin

CAT: 0804-HY-111934-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111934-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX) -induced K+ release (IC50=0.42 μM) . Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant[1][2][3][4].
CAS Number
508-77-0
UNSPSC
12352005
Hazard Statement
H301+H331, H373
Target
Parasite; Potassium Channel
Type
Natural Products
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Field of Research
Cancer; Others
Assay Protocol
https://www.medchemexpress.com/cymarin.html
Purity
97.82
Solubility
10 mM in DMSO
Smiles
O=C[C@@]12[C@]3([H])[C@](CC[C@@]1(C[C@@H](O[C@@]4([H])C[C@@H]([C@H](O)[C@@H](C)O4)OC)CC2)O)([H])[C@@]5([C@@](C)([C@@H](C(CO6)=CC6=O)CC5)CC3)O
Molecular Formula
C30H44O9
Molecular Weight
548.66
Precautions
H301+H331, H373
References & Citations
[1]Ozaki H, et al. Interaction of palytoxin and cardiac glycosides on erythrocyte membrane and (Na+ + K+) ATPase. Eur J Biochem. 1985;152 (2) :475-480. |[2]Li Q, et al., Translation of paired box 6 (PAX6) mRNA is IRES-mediated and inhibited by cymarin in breast cancer cells. Genes Genet Syst. 2023 Oct 24;98 (4) :161-169.|[3]Akhtar Y, et al., Comparative growth inhibitory and antifeedant effects of plant extracts and pure allelochemicals on four phytophagous insect species. J Applied Entomology. 10 February 2004.128,32-38.|[4]Tan L, et al., A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells. J Mol Cell Biol. 2023 Nov 27;15 (6) :mjad039.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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CatalogName
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