RegisterLogin

ML281

CAT: 0804-HY-13495-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13495-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
ML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA. target: STK33 IC50: 14 nM [1] ML281 showed low nanomolar inhibition of purified recombinant STK33 and a distinct selectivity profile as compared to other STK33 inhibitors. Even at the highest concentration tested (10 μM), ML281 had no effect on the viability of KRAS-dependent cancer cells. [2]
CAS Number
[1404437-62-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
STK33
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ML281.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC2=CC=CC=C2N=C1C3=CC(C(C)C)=CC=C3NC(C4=CC=CS4)=O
Molecular Formula
C22H19N3O2S
Molecular Weight
389.47
Precautions
H302, H315, H319, H335
References & Citations
[1]We?wer M et al. A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett, 2012 Dec 13, 3 (12) :1034-1038.|[2]Spoonamore J et al. Screen for Inhibitors of STK33 Kinase Activity. National Center for Biotechnology Information (US) ; 2010-2011 Dec 16.|[3]Sun EL, et al. Knockdown of human serine/threonine kinase 33 suppresses human small cell lung carcinoma by blocking RPS6/BAD signaling transduction. Neoplasma. 2017;64 (6) :869-879.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-103309-01ML218
HY-19630-01ML289
HY-111179-01ML261
HY-101991-01ML291
HY-12607-01ML251
HY-19797-01ML241
HY-173018-01ML283
HY-103254-01ML221
HY-19797A-01ML241 (hydrochloride)
HY-103309S-01ML218-d9

Alternative Products

CatalogName
M17278-01ML281

Popular Products