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Anagyrine

CAT: 0804-HY-121027-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121027-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Anagyrine ((-) -Anagyrine) is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine binds to muscarinic and nicotinic acetylcholine receptors with IC50 values of 132 and 2096 µM respectively. Anagyrine is a potent and effective desensitizer of nAChR, and Anagyrine can directly, without metabolism, desensitize nAChR[1][2][3].
CAS Number
486-89-5
Product Name Alternative
(-) -Anagyrine; Monolupine; Rhombinine
UNSPSC
12352005
Hazard Statement
H301, H360
Target
MAChR; nAChR
Type
Natural Products
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/anagyrine.html
Purity
98.15
Solubility
DMSO : 25 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)
Smiles
O=C1N2C([C@]3([H])C[C@]([C@]4([H])N(CCCC4)C3)([H])C2)=CC=C1
Molecular Formula
C15H20N2O
Molecular Weight
244.33
Precautions
H301, H360
References & Citations
[1]Schmeller T, et al. Binding of quinolizidine alkaloids to nicotinic and muscarinic acetylcholine receptors. J Nat Prod. 1994 Sep;57 (9) :1316-9.|[2]Matsuda, K., et al. Nematicidal activities of (–) -N-methylcytisine and (–) -anagyrine from Sophora flavescens against pine wood nematodes. Agr. BioI. Chem. 53 (8), 2287-2288 (1989) .|[3]Green BT, et al. Anagyrine desensitization of peripheral nicotinic acetylcholine receptors. A potential biomarker of quinolizidine alkaloid teratogenesis in cattle. Res Vet Sci. 2017 Dec;115:195-200.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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