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Tribuloside

CAT: 0804-HY-N2443-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N2443-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tribuloside is a flavonoid and PDE4 inhibitor (IC50: 6 μM) . Tribuloside exhibits antibacterial and antioxidant activities, capable of scavenging DPPH free radicals. Tribuloside also promotes melanogenesis. Tribuloside can be used in the research of hypopigmentary diseases, sun protection, and inflammatory diseases such as acute lung injury[1][2][3].
CAS Number
22153-44-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Bacterial; Interleukin Related; Microphthalmia Associated Transcription Factor (MITF) ; Phosphodiesterase (PDE) ; PKA; TRP Channel; Tyrosinase
Type
Natural Products
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Infection; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tribuloside.html
Purity
99.26
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1C(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)COC(/C=C/C3=CC=C(O)C=C3)=O)=C(C4=CC=C(O)C=C4)OC5=CC(O)=CC(O)=C51
Molecular Formula
C30H26O13
Molecular Weight
594.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Christopher R, et al. A new cinnamoylglycoflavonoid, antimycobacterial and antioxidant constituents from Heritiera littoralis leaf extracts. Nat Prod Res. 2014;28 (6) :351-8.|[2]Cao Y, et al. Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport. J Ethnopharmacol. 2024 Apr 6;323:117673.|[3]Yang Z, et al. Tribuloside: Mechanisms and Efficacy in Treating Acute Lung Injury Revealed by Network Pharmacology and Experimental Validation. Dose Response. 2024 May 8;22 (2) :15593258241251594.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IL-1; IL-6; PDE4

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