Tribuloside

• Description :

  Tribuloside is a flavonoid and PDE4 inhibitor (IC50: 6 μM) . Tribuloside exhibits antibacterial and antioxidant activities, capable of scavenging DPPH free radicals. Tribuloside also promotes melanogenesis. Tribuloside can be used in the research of hypopigmentary diseases, sun protection, and inflammatory diseases such as acute lung injury[1][2][3].

• CAS Number :

  [22153-44-2]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Bacterial; Interleukin Related; Microphthalmia Associated Transcription Factor (MITF) ; Phosphodiesterase (PDE) ; PKA; TRP Channel; Tyrosinase

• Type :

  Natural Products

• Related Pathways :

  Anti-infection; Cell Cycle/DNA Damage; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Metabolic Disease; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/tribuloside.html

• Purity :

  99.26

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  O=C1C(O[C@@H]2O[C@@H]([C@@H](O)[C@H](O)[C@H]2O)COC(/C=C/C3=CC=C(O)C=C3)=O)=C(C4=CC=C(O)C=C4)OC5=CC(O)=CC(O)=C51

• Molecular Formula :

  C30H26O13

• Molecular Weight :

  594.52

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Christopher R, et al. A new cinnamoylglycoflavonoid, antimycobacterial and antioxidant constituents from Heritiera littoralis leaf extracts. Nat Prod Res. 2014;28 (6) :351-8.|[2]Cao Y, et al. Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport. J Ethnopharmacol. 2024 Apr 6;323:117673.|[3]Yang Z, et al. Tribuloside: Mechanisms and Efficacy in Treating Acute Lung Injury Revealed by Network Pharmacology and Experimental Validation. Dose Response. 2024 May 8;22 (2) :15593258241251594.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  IL-1; IL-6; PDE4