Pancuronium (dibromide)

• Description :

  Pancuronium dibromide, a bis-quaternary steroid, is a neuromuscular relaxant. Pancuronium dibromide inhibits neuromuscular transmission by competing with acetylcholine for binding sites on nACh receptors. Pancuronium dibromide also inhibits cardiac muscarinic receptors and has a sympathomimetic action[1][2][3].

• UNSPSC :

  12352005

• Hazard Statement :

  H301

• Target :

  NAChR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/Pancuronium-dibromide.html

• Purity :

  98.0

• Solubility :

  DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)

• Smiles :

  C[N+]1([C@@H]2[C@@H](OC(C)=O)C[C@@](CC[C@]3([H])[C@]4([H])CC[C@@]5(C)[C@@]3([H])C[C@H]([N+]6(C)CCCCC6)[C@@H]5OC(C)=O)([H])[C@]4(C)C2)CCCCC1.[Br-].[Br-]

• Molecular Formula :

  C35H60Br2N2O4

• Molecular Weight :

  732.67

• Precautions :

  H301

• References & Citations :

  [1]A D Fryer, et al. Pancuronium and gallamine are antagonists for pre- and post-junctional muscarinic receptors in the guinea-pig lung. Naunyn Schmiedebergs Arch Pharmacol. 1987 Apr;335 (4) :367-71.|[2]E Maestrone, et al. Extracellular pancuronium affects sodium current in chick embryo sensory neurons. Br J Pharmacol. 1994 Jan;111 (1) :283-7.|[3]J R Docherty, et al. A comparison of the effects of pancuronium bromide and its monoquaternary analogue, ORG NC 45, on autonomic and somatic neurotransmission in the rat. Br J Pharmacol. 1980;71 (1) :225-33.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [15500-66-0]