6-O-Isobutyrylbritannilactone

6-O-Isobutyrylbritannilactone

• CAS Number: 1259933-02-2
• UNSPSC Description: 6-O-Isobutyrylbritannilactone is a natural melanogenesis inhibitor. 6-O-Isobutyrylbritannilactone, a sesquiterpene, can be isolated from the flowers of Inula britannica. 6-O-Isobutyrylbritannilactone inhibits IBMX (HY-12318)-induced melanin production in B16F10 cells. 6-O-Isobutyrylbritannilactone also regulates ERK, PI3K/AKT, and CREB, shows antimelanogenic activity in zebrafish embryos models[1].
• Target Antigen: Akt; Epigenetic Reader Domain; ERK; PI3K
• Type: Natural Products
• Related Pathways: Epigenetics;MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/6-o-isobutyrylbritannilactone.html
• Solubility: 10 mM in DMSO
• Smiles: CC(C)C(O[C@H]1[C@@]2([H])[C@@](OC(C2=C)=O)([H])CC(C)=C1[C@@H](C)CCCO)=O
• Molecular Weight: 336.42
• References & Citations: [1]Jang DK, et al. Anti-Melanogenesis Activity of 6-O-Isobutyrylbritannilactone from Inula britannica on B16F10 Melanocytes and In Vivo Zebrafish Models. Molecules. 2020 Aug 26;25(17):3887.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported