Cassiaside

• Description :

  Cassiaside is a naphthopyrone glucoside, shows mixed-type inhibition against BACE1 (IC50=4.45 μM; Ki=9.85 μM) . Cassiaside possesses potential anti- Alzheimer's disease (AD) activity[1].

• UNSPSC :

  12352005

• Target :

  Beta-secretase

• Type :

  Natural Products

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cassiaside.html

• Purity :

  99.67

• Solubility :

  DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  OC1=C(C2=O)C(OC(C)=C2)=CC3=C1C(O[C@@H]([C@@H]([C@H]4O)O)O[C@@H]([C@H]4O)CO)=CC(O)=C3

• Molecular Formula :

  C20H20O10

• Molecular Weight :

  420.37

• References & Citations :

  [1]Jung HA, et al. Inhibitory activities of major anthraquinones and other constituents from Cassia obtusifolia against β-secretase and cholinesterases. J Ethnopharmacol. 2016;191:152-160.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  BACE1

• CAS Number :

  [13709-03-0]