A-1155463

CAT: 0804-HY-19725-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-19725-01Size:5 mg
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Description
A-1155463, a chemical probe, is a highly potent and selective BCL-XL inhibitor with an EC50 of 70 nM in Molt-4 cell. A-1155463 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[1235034-55-5]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/A-1155463.html
Concentration
10mM
Purity
99.62
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O
Molecular Formula
C35H32FN5O4S2
Molecular Weight
669.79
Precautions
H302, H312, H332
References & Citations
[1]Leverson JD, et al. Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy. Sci Transl Med.?2015 Mar 18;7 (279) :279|[2]Tao ZF, et al. Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity. ACS Med Chem Lett. 2014 Aug 26;5 (10) :1088-93.|[3]Zhang H, et al. Genomic analysis and selective small molecule inhibition identifies BCL-X (L) as a critical survival factor in a subset of colorectal cancer. Mol Cancer. 2015 Jul 2;14:126.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-xL

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