Products for Research Use Only
RegisterLogin

Apafant

CAT: 0804-HY-108634-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-108634-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Apafant (WEB 2086), a chemical probe, is a potent platelet-activating factor (PAF) antagonist, inhibits PAF binding to human PAF receptors with a Ki of 9.9 nM. Apafant increases the gene expression of PAF-r, α-globin, β-globin, decreases the c-myb gene expression. Apafant shows a protective effect on alkyl-PAF-mediated lethalit[1][2][3].
CAS Number
105219-56-5
Product Name Alternative
WEB 2086
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Platelet-activating Factor Receptor (PAFR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/apafant.html
Purity
99.96
Solubility
DMSO : 40 mg/mL (ultrasonic; warming)
Smiles
O=C(N1CCOCC1)CCC(S2)=CC3=C2N4C(CN=C3C5=CC=CC=C5Cl)=NN=C4C
Molecular Formula
C22H22ClN5O2S
Molecular Weight
455.96
Precautions
H302, H315, H319, H335
References & Citations
[1]Kato M, et al. Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs. J Pharmacol Sci. 2004 Aug;95 (4) :435-42.|[2]Cellai C, Laurenzana A, Vannucchi AM, Della Malva N, Bianchi L, Paoletti F. Specific PAF antagonist WEB-2086 induces terminal differentiation of murine and human leukemia cells. FASEB J. 2002 May;16 (7) :733-5.|[3]Chaithra VH, et al. Modulation of inflammatory platelet-activating factor (PAF) receptor by the acyl analogue of PAF. J Lipid Res. 2018 Nov;59 (11) :2063-2074.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

Alternative Products

CatalogName
A726100Apafant
sc-217657Apafant-d8
A19904-1Apafant 1mg
A19904-50Apafant 50mg
A19904-10Apafant 10mg
A19904-5Apafant 5mg
A19904-100Apafant 100mg
A19904-25Apafant 25mg

Popular Products