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Sulfathiazole

CAT: 0804-HY-B0507-01Size: 10 gDry Ice: NoHazardous: No
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CAT#:0804-HY-B0507-01Size:10 g
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Description
Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish[1][2][3].
CAS Number
72-14-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/sulfathiazole.html
Concentration
10mM
Purity
99.71
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=S(C1=CC=C(N)C=C1)(NC2=NC=CS2)=O
Molecular Formula
C9H9N3O2S2
Molecular Weight
255.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Ji K, Choi K, Lee S, Park S, Khim JS, Jo EH, Choi K, Zhang X, Giesy JP. Effects of sulfathiazole, oxytetracycline and chlortetracycline on steroidogenesis in the human adrenocarcinoma (H295R) cell line and freshwater fish Oryzias latipes. J Hazard Mater. 2010 Oct 15;182 (1-3) :494-502.|[2]Endicott, et al. Lesions in rats given sulfathiazole, sulfadiazine, sulfanilamide, sulfamerazine, sulfapyrazine, or acetylsulfadiazine in purified diets. Public Health Reports (1896-1970) (1944) : 49-54.|[3]Zor, et al. Sulfathiazole as potential corrosion inhibitor for copper in 0.1 M NaCl. Protection of Metals and Physical Chemistry of Surfaces 50 (2014) : 530-537.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
ACS Environ Au. 2025 Aug 8.|Anal Chem. 2025 Jun 3;97 (21) :11099-11109.|Chemosphere. 2019 Jun:225:378-387.|Theranostics. 2022 Jan 1;12 (3) :1187-1203.|Research Square Preprint. 2021 Aug.

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CatalogName
289248-01Sulfathiazole

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