E4177

CAT: 0804-HY-106890-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-106890-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

E4177 (57G709) is an orally active angiotensin II receptor antagonist. E4177 can inhibit the growth of vascular smooth muscle cells (HASMC) and the increase of cell surface area. In addition, E4177 can also increase the expression of platelet-derived growth factor (PDGF) receptor. E4177 can be used in the study of vascular diseases[1].

CAS Number

135070-05-2

Product Name Alternative

57G709

UNSPSC

12352005

Target

Angiotensin Receptor; PDGFR

Type

Reference compound

Related Pathways

GPCR/G Protein; Protein Tyrosine Kinase/RTK

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/e4177.html

Smiles

O=C(C1=C(C2=CC=C(CN3C4=NC=CC(C)=C4N=C3C5CC5)C=C2)C=CC=C1)O

Molecular Formula

C24H21N3O2

Molecular Weight

383.44

References & Citations

[1]Kuma S, et al. ANGIOTENSIN II‐INDUCED GROWTH OF VASCULAR SMOOTH MUSCLE CELLS IS ASSOCIATED WITH MODULATION OF CELL SURFACE AREA AND PLATELET‐DERIVED GROWTH FACTOR RECEPTOR EXPRESSION[J]. Clinical and experimental pharmacology and physiology, 2007, 34 (3) : 153-160.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 2

E4177

Popular Products