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Rafoxanide

CAT: 0804-HY-17598-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17598-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rafoxanide is a poent, orally active halogenated salicylaniline agent with antiparasitic activity. Rafoxanide interferes with energy metabolism in trematodes by uncoupling oxidative phosphorylation. Rafoxanide is also found to be a potent inhibitor of the BRAF V600E mutant protein, which is important in colorectal cancer. Rafoxanide can be used for the control of infestation with Hemonchus species or Fasciola species in sheep and cattle as well as Oestrus ovis in sheep. Rafoxanide can also be used for cancer research[1][2][3].
CAS Number
22662-39-1
UNSPSC
12352005
Hazard Statement
H302, H413
Target
Apoptosis; Oxidative Phosphorylation; p38 MAPK; Parasite; Raf
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/Rafoxanide.html
Purity
98.60
Solubility
DMSO : ≥ 31 mg/mL
Smiles
O=C(NC1=CC=C(OC2=CC=C(Cl)C=C2)C(Cl)=C1)C3=CC(I)=CC(I)=C3O
Molecular Formula
C19H11Cl2I2NO3
Molecular Weight
626.01
Precautions
H302, H413
References & Citations
[1]El-Banna HA, et, al. Comparative pharmacokinetics of ivermectin alone and a novel formulation of ivermectin and rafoxanide in calves and sheep. Parasitol Res. 2008 May;102 (6) :1337-42.|[2]van Wyk JA, et, al. Two field strains of Haemonchus contortus resistant to rafoxanide. Onderstepoort J Vet Res. 1987 Jun;54 (2) :143-6.|[3]Laudisi F, et al. Induction of endoplasmic reticulum stress and inhibition of colon carcinogenesis by the anti-helmintic drug rafoxanide. Cancer Lett. 2019;462:1-11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Schistosome

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