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DPLG3

CAT: 0804-HY-P10030-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P10030-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DPLG3 is a specific chymotryptic-like β5i subunits inhibitor, with an IC50 of 4.5 nM. DPLG3 inhibits mouse i-20S with IC50 of 9.4 nM. DPLG3 downregulates the protein levels of NF-κB p50 and p65. DPLG3 can be used for immune disease research[1][2][3].
CAS Number
1801379-22-5
UNSPSC
12352209
Target
NF-κB; Proteasome
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dplg3.html
Purity
99.18
Solubility
10 mM in DMSO
Smiles
FC(C=C1)=CC=C1C[C@H](NC([C@H](CC(NOC(C)(C)C)=O)NC(CCC2=CC=CC=C2)=O)=O)C(NCC3=CC=CC4=C3C=CC=C4)=O
Molecular Formula
C37H41FN4O5
Molecular Weight
640.74
References & Citations
[1]Moallemian R, et al. Immunoproteasome inhibitor DPLG3 attenuates experimental colitis by restraining NF-κB activation. Biochem Pharmacol. 2020 Jul;177:113964.|[2]Sula Karreci E, et al. Brief treatment with a highly selective immunoproteasome inhibitor promotes long-term cardiac allograft acceptance in mice. Proc Natl Acad Sci U S A. 2016 Dec 27;113 (52) :E8425-E8432. |[3]Basler M, et al. On the role of the immunoproteasome in transplant rejection. Immunogenetics. 2019 Mar;71 (3) :263-271.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
NF-κB1/p50; RelA/p65

Chemical Information

CID 91824176
CAS Number1801379-22-5
PubChem CID91824176
IUPAC Name(2S)-N-[(2S)-3-(4-fluorophenyl)-1-(naphthalen-1-ylmethylamino)-1-oxopropan-2-yl]-N'-[(2-methylpropan-2-yl)oxy]-2-(3-phenylpropanoylamino)butanediamide
Molecular FormulaC37H41FN4O5
Molecular Weight640.7
XLogP5.3
Topological Polar Surface Area126
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count15
Heavy Atom Count47
Formal Charge0
Complexity1020
SMILES
CC(C)(C)ONC(=O)C[C@@H](C(=O)N[C@@H](CC1=CC=C(C=C1)F)C(=O)NCC2=CC=CC3=CC=CC=C32)NC(=O)CCC4=CC=CC=C4
InChI
InChI=1S/C37H41FN4O5/c1-37(2,3)47-42-34(44)23-32(40-33(43)21-18-25-10-5-4-6-11-25)36(46)41-31(22-26-16-19-29(38)20-17-26)35(45)39-24-28-14-9-13-27-12-7-8-15-30(27)28/h4-17,19-20,31-32H,18,21-24H2,1-3H3,(H,39,45)(H,40,43)(H,41,46)(H,42,44)/t31-,32-/m0/s1
InChIKey
DDEQIWLWJUDFKG-ACHIHNKUSA-N
Chemical Structure
2D Structure
2D structure of CID 91824176
CAS: 1801379-22-5
CID: 91824176
Formula: C37H41FN4O5
MW: 640.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight640.7
XLogP35.3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count15
Exact Mass640.30609858
Monoisotopic Mass640.30609858
Topological Polar Surface Area126 Ų
Heavy Atom Count47
Formal Charge0
Complexity1020
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
MBS5824181DPLG3

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