Biotin Conjugated Human IFN-alpha Recombinant Rabbit Monoclonal Antibody [PS00-79] - BSA and Azide free (Detector)

Biotin Conjugated Human IFN-alpha Recombinant Rabbit Monoclonal Antibody [PS00-79] - BSA and Azide free (Detector)

• Description: IFN-alpha is a pharmaceutical drug composed of natural interferon alpha (IFN-α). Interferon alfa is used in a variety of treatments, including certain forms of leukemia, malignant melanoma, non-Hodgkin's lymphoma, hepatitis B, and hepatitis C. It is typically administered as an injection under the skin. Interferon alfa contains a mixture of several proteins, all with structural, serological, and functional properties typical for natural interferon alpha (IFN-α). IFN-α8 enhances the proliferation of human B cells, as well as being able to activate NK cells. The subtypes α10 and α2, along with α8, are the most efficient and powerful NK cell activators. Subtypes α21 and α2 enhance the expression of IFN-gamma-inducible protein-10 (IP-10) in dendritic cells. Activated dendritic cells initiate immune responses and induce the expression of IP-10, a chemokine which promotes a Th1 inflammatory response. IFN-α1 causes increased HLA-II expression, and can directly inhibit tumor cell growth in vitro. However, it is a poor activator of NK cells, has relatively little antiviral activity, does not induce B cell proliferation, and does not enhance HLA-I or tumor antigen expression. Despite its apparent inactivity, it is still used clinically in the treatment of metastatic renal cell carcinoma, with a reported lower toxicity than the recombinant IFN-α2. Overall, IFN-α has a general inflammatory action which skews the immune response towards a Th1 profile.
• Product Name Alternative: IFL antibody IFN alpha antibody IFN alpha 1/13 antibody IFN alpha 1b antibody IFN alphaD antibody IFN antibody IFN-alpha-1/13 antibody IFNA@ antibody IFNA1 antibody IFNA1_HUMAN antibody IFNA13 antibody Interferon alpha 1 antibody Interferon alpha-1/13 antibody Interferon alpha-D antibody Interferon alpha1 antibody Interferon, alpha 13 antibody LeIF D antibody
• Abbreviation: IFNA1 Interferon alpha-1/13 IFN-alpha-1/13 Interferon alpha-D (LeIF D) IFNA13
• CAS Number: 9000-83-3
• Swiss Prot: P01562 Human
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant full length protein.
• Isotype: IgG
• Clone: PS00-79
• Conjugation: Biotin-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: ELISA (Det)
• Positive Control: Recombinant human IFN-alpha protein.
• Concentration: 1 mg/mL
• Dilution: ELISA (Det): Use at an assay dependent concentration. Can be paired for Sandwich ELISA with Rabbit monoclonal [PS00-80] to IFN-alpha (Capture) (HA721290).
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4).
• Molecular Weight: Predicted band size: 22 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes