ITGAV (light chain, Cleaved-Asp891) rabbit pAb

ITGAV (light chain, Cleaved-Asp891) rabbit pAb

• Description: Integrin subunit alpha V (ITGAV) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],
• Synonyms: Integrin alpha-V (Vitronectin receptor subunit alpha;CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
• Gene ID: 3685
• UniProt: P06756
• Cellular Locus: Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthesized peptide derived from human ITGAV (light chain, Cleaved-Asp891)
• Clonality: Polyclonal
• Validated Applications: WB, ELISA, IHC
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
• Molecular Weight: 17 110kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.