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Intoplicine

CAT: 0804-HY-101647-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101647-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Intoplicine (RP 60475), an antitumor derivative in the 7H-benzo[e]pyrido[4,3-b]indole series, is a DNA topoisomerase I and II inhibitor. Intoplicine strongly binds DNA (KA = 2 x 105 /M) and thereby increases the length of linear DNA[1][2].
CAS Number
125974-72-3
Product Name Alternative
RP 60475
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Intoplicine.html
Purity
98.36
Solubility
DMSO : 80 mg/mL (ultrasonic)
Smiles
OC1=CC=C2C3=C(NC4=C3C(NCCCN(C)C)=NC=C4C)C=CC2=C1
Molecular Formula
C21H24N4O
Molecular Weight
348.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Eckardt JR, et al. Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. J Natl Cancer Inst. 1994 Jan 5;86 (1) :30-3.|[2]Morjani H, et al. Molecular and cellular interactions between Intoplicine, DNA, and topoisomerase II studied by surface-enhanced Raman scattering spectroscopy. Cancer Res. 1993 Oct 15;53 (20) :4784-90.|[3]Bissery MC, et al. Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in mice. Invest New Drugs. 1993;11 (4) :263-277.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Topo I; Topo II

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