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Fabomotizole

CAT: 0804-HY-14895-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14895-01Size:5 mg
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Description
Fabomotizole (CM346) is an insecticide with anxiolytic, antianxiety, and neuroprotective activities and a substrate of p-glycoprotein. Fabomotizole inhibits the ST-segment depression induced by isoproterenol in a rat model of acute subendocardial ischemia. Fabomotizole also inhibits Giardia lamblia and has the potential to inhibit giardiasis. Fabomotizole also targets Sigma1R, NRH:quinone reductase 2 (NQO2), and MAO-A to exert anxiolytic effects[1][2][3].
CAS Number
173352-21-1
Product Name Alternative
CM346
UNSPSC
12352005
Hazard Statement
H302
Target
Monoamine Oxidase; Parasite; P-glycoprotein; Sigma Receptor
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Fabomotizole.html
Purity
98.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCOC1=CC=C2C(N=C(SCCN3CCOCC3)N2)=C1
Molecular Formula
C15H21N3O2S
Molecular Weight
307.41
Precautions
H302
References & Citations
[1]Tsorin IB, et al. Anti-Ischemic Activity of Fabomotizole Hydrochloride under Conditions of Endothelial Dysfunction. Bull Exp Biol Med. 2019 Sep;167 (5) :634-636. |[2]Pérez-Villanueva J, et al. The giardicidal activity of lobendazole, fabomotizole, tenatoprazole and ipriflavone: A ligand-based virtual screening and in vitro study. Eur J Med Chem. 2021 Feb 5;211:113110. |[3]Chernykh I V, et al. Study of fabomotizole belonging to p-glycoprotein substrates[J]. IP Pavlov Russian Medical Biological Herald, 2017, 25 (4) : 538-550.|[4]Voronin MV, Vakhitova YV, Tsypysheva IP, Tsypyshev DO, Rybina IV, Kurbanov RD, Abramova EV, Seredenin SB. Involvement of Chaperone Sigma1R in the Anxiolytic Effect of Fabomotizole. Int J Mol Sci. 2021 May 21;22 (11) :5455.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
MAO-A; Sigma 1 Receptor

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