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SJ3149

CAT: 0804-HY-160444-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-160444-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SJ3149 is a selective and potent molecular glue degrader of CK1α protein with broad antiproliferative activity. SJ3149 can be used in cancer research[1][2].
CAS Number
3026986-17-1
UNSPSC
12352005
Target
Casein Kinase; Molecular Glues
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sj3149.html
Purity
99.48
Solubility
DMSO : 75 mg/mL (ultrasonic)
Smiles
O=C1N(C2C(NC(CC2)=O)=O)CC3=C1C=CC(NC4=NOC5=C4C=CC=C5)=C3
Molecular Formula
C20H16N4O4
Molecular Weight
376.37
References & Citations
[1]Nishiguchi G, et al. Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines. Nat Commun. 2024 Jan 16;15 (1) :482.|[2]Rankovic Z, et al. Rationally Designed Potent and Selective CK1α Degraders Exert Antiproliferative Activity Against a Broad Range of Human Cancer Cell Lines[J]. 2023.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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