Mouse IFN-alpha / beta R2 Protein, His Tag

Mouse IFN-alpha / beta R2 Protein, His Tag

• Background: Interferon alpha/beta receptor 2 (IFNAR2) is also known as IFN-alpha binding protein, IFN-alpha/beta receptor 2, Type I interferon receptor 2, IFNABR and IFNARB, which is a single-pass type I membrane protein and belongs to the type II cytokine receptor family. IFNAR2 can associate with IFNAR1 to form the type I interferon receptor. IFNAR2 is a receptor for interferons alpha and beta.IFNAR2 involves in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 of IFNAR2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 of IFNAR2 is a potent inhibitor of type I IFN receptor activity.Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection.
• Description: Mouse IFN-alpha / beta R2, His Tag (IF2-M5225) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Ala 242 (Accession # O35664-1).
• Specifications: This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 26.6 kDa. The protein migrates as 45-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expression Region: Ser 22 - Ala 242
• Host: HEK 293
• Target: IFN-alpha/beta R2
• Conjugation: Unconjugated
• Tag: C-10×His
• Source: Mouse
• Stability: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Endotoxin: 1.0 EU per μg
• Purity: 95%
• Format: Powder
• Buffer: PBS, pH7.4
• Additives: Trehalose
• Molecular Weight: 26.6 kDa
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C