NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)

• CAS Number: 2891469-81-9
• UNSPSC Description: NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40), a macrocyclic analogue of Ape13, is a potent APJ agonist (Ki=5.7 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) exhibits a favorable Gα12-biased signaling and an increased in vivo half-life[1].
• Target Antigen: Apelin Receptor (APJ)
• Type: Peptides
• Related Pathways: GPCR/G Protein
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/nh2-c-x-r-l-s-x-k-g-p-d-2nal.html
• Solubility: 10 mM in DMSO
• Smiles: N[C@@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N2CCC[C@H]2C(N[C@H](CC3=CC=C4C=CC=CC4=C3)C(O)=O)=O)=O)=O)CCCCN)=O)C/C=C\C1)=O)CO)=O)CC(C)C)=O)CCCNC(N)=N)=O
• Molecular Weight: 1020.18
• References & Citations: [1]Tran K, et, al. Size-Reduced Macrocyclic Analogues of [Pyr 1]-apelin-13 Showing Negative Gα 12 Bias Still Produce Prolonged Cardiac Effects. J Med Chem. 2022 Jan 13;65(1):531-551.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported