Z57346765

CAT: 0804-HY-W195984-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-W195984-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Z57346765 is a PGK1-specific inhibitor that reduces the activity of metabolic enzymes in PGK1 glycolysis and inhibits PGK1-dependent cell proliferation. Z57346765 exerts inhibitory effects against clear cell renal cell carcinoma (KIRC) [1].

CAS Number

1016340-64-9

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Phosphoglycerate Kinase (PGK)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z57346765.html

Purity

99.59

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OCCNC1=C2C=CC=CC2=NC(NC3=CC=C(C)C=C3)=N1

Molecular Formula

C17H18N4O

Molecular Weight

294.36

Precautions

H315, H319, H335

References & Citations

[1]He Y, et al. Novel inhibitors targeting the PGK1 metabolic enzyme in glycolysis exhibit effective antitumor activity against kidney renal clear cell carcinoma in vitro and in vivo. Eur J Med Chem. 2024 Mar 5;267:116209.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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