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Lazabemide

CAT: 0804-HY-14201-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14201-01Size:5 mg
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Description
Lazabemide (Ro 19-6327) is a selective, reversible inhibitor of monoamine oxidase B (MAO-B) (IC50=0.03 μM) but less active for MAO-A (IC50>100 μM) . Lazabemide inhibits monoamine uptake at high concentrations, the IC50 values are 86 μM, 123 μM and >500 μM for noradrenalin, serotonin and dopamine uptake, respectively. Lazabemide can be used for the research of parkinson and alzheimer′s disease[1].
CAS Number
103878-84-8
Product Name Alternative
Ro 19-6327
UNSPSC
12352005
Hazard Statement
H302, H319
Target
Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Lazabemide.html
Purity
99.95
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
ClC1=CC=C(C(NCCN)=O)N=C1
Molecular Formula
C8H10ClN3O
Molecular Weight
199.64
Precautions
H302, H319
References & Citations
[1]Saura J, et al. Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J Neurosci. 1992 May;12 (5) :1977-99.|[2]Bondiolotti GP, et al. In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemide and N- (2-aminoethyl) -p-chlorobenzamide: a comparison with L-deprenyl. Biochem Pharmacol. 1995 Jun 29;50 (1) :97-102.|[3]Guimaraes J, et al. The activity of MAO A and B in rat renal cells and tubules. Life Sci. 1998;62 (8) :727-37.|[4]Suzuki T, et al. MAO inhibitors, clorgyline and lazabemide, prevent hydroxyl radical generation caused by brain ischemia/reperfusion in mice. Pharmacology. 1995 Jun;50 (6) :357-62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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