Anti-SUR1 Antibody

Anti-SUR1 Antibody

• Description: Mouse Monoclonal Antibody specific to SUR1
• Product Name Alternative: Sulfonylurea receptor 1
• CAS Number: 9007-83-4
• Gene Name: Abcc8
• NCBI Gene ID: Abcc8
• UniProt: Q09429
• Accession Number: NP_037171.2
• Cellular Locus: Cell membrane, Multi-pass membrane protein
• Host: Mouse
• Reactivity: Human, Mouse, Rat
• Immunogen: Fusion protein corresponding to aa 1548-1582 (cytoplasmic C-terminus) of rat SUR1 (accession no. NP_037171.2).
• Target Antigen: ATP-binding cassette sub-family C member 8
• Target: SUR1
• Clonality: Monoclonal
• Isotype: IgG1
• Type: Antibody
• Applications: WB, IHC, ICC/IF
• Field of Research: Ion Channels
• Purification Method: Purified by Protein G affinity chromatography
• Concentration: Lot Specific
• Dilution: Dilute in PBS or medium which is identical to that used in the assay system.
• Format: Purified
• Form: Liquid
• Buffer: Phosphate Buffered Saline
• Function: Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. {UniProtKB:Q09428}.
• Additionnal Information: Immunoblotting: use at 1-2ug/mL. A band of ~160kDa is detected.
  
  Immunohistochemistry: use at 1-10ug/mL.
  
  These are recommended concentrations. User should determine optimal concentrations for their application.
  
  Positive control: Mouse brain membranes.
• Storage Conditions: This antibody is stable for at least one (1) year at -20°C.
• Specificity: This antibody recognizes human, mouse, and rat SUR1. It does not cross-react with SUR2B.
• Formulation: PBS, pH 7.4; 50% glycerol, 0.09% sodium azide.
• Buffer pH: pH 7.4
• Target Background: Sulfonylurea receptors (SUR) are membrane proteins that are molecular targets of the sulfonylurea class of antidiabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the SUR is to sense intracellular levels of ATP and ADP and facilitate the opening or closing of its associatedKir6.x potassium channel, thus monitoring the energy balance within cells.