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AQP7 rabbit pAb

CAT: 0855-ES18279-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a member of the aquaporin family of water-selective membrane channels. The encoded protein localizes to the plasma membrane and allows movement of water, glycerol and urea across cell membranes. This gene is highly expressed in the adipose tissue where the encoded protein facilitates efflux of glycerol. In the proximal straight tubules of kidney, the encoded protein is localized to the apical membrane and prevents excretion of glycerol into urine. The encoded protein is present in spermatids, as well as in the testicular and epididymal spermatozoa suggesting an important role in late spermatogenesis. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related aquaporin gene on chromosome 9. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Dec 2015]
Description
This gene encodes a member of the aquaporin family of water-selective membrane channels. The encoded protein localizes to the plasma membrane and allows movement of water, glycerol and urea across cell membranes. This gene is highly expressed in the adipose tissue where the encoded protein facilitates efflux of glycerol. In the proximal straight tubules of kidney, the encoded protein is localized to the apical membrane and prevents excretion of glycerol into urine. The encoded protein is present in spermatids, as well as in the testicular and epididymal spermatozoa suggesting an important role in late spermatogenesis. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. This gene is located adjacent to a related aquaporin gene on chromosome 9. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Dec 2015],
UniProt
O14520
Swiss Prot
O14520
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human AQP7 AA range: 136-186
Target
AQP7
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein . Cytoplasm, cell cortex . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Lipid droplet . Internalized from the cell membrane in response to catecholamine-induced activation of PKA; detected on intracellular membranes and colocalizes with lipid droplets (By similarity) . Colocalizes with PLIN1 in adipocytes, probably on lipid droplets (PubMed:27832861) . .
Gene ID (Human)
364

UniProtKB · O14520

Aquaporin-7

AQP7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14520
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AQP7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
AQP-7
EC number
—
Processing
—
Secondary accessions
Q08E94, Q5T5L9, Q8NHM3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCytoplasmic vesicleLipid dropletMembrane

PTM

Phosphoprotein

Domain

RepeatTransmembraneTransmembrane helix

Biological process

Transport

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