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YM114

CAT: 0804-HY-106909ASize: 1 EachDry Ice: NoHazardous: No
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Description
YM114 (KAE-393) is a highly potent and selective (5-HT) 3-receptor antagonist that does not affect Veratridine - or electrical stimulation-induced bradycardia in anesthetized rats. YM114 inhibits 2-methyl-5-HT (HY-19358) -induced Bezold-Jarisch reflex, which originates from (5-HT) 3-receptor located on the endings of vagal afferent nerves in the heart[1].
CAS Number
153608-99-2
Product Name Alternative
KAE-393
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ym114.html
Smiles
O=C([C@H]1CC2=C(N=CN2)CC1)N3C4=CC=CC=C4CC3.Cl
Molecular Formula
C16H18ClN3O
Molecular Weight
303.79
References & Citations
[1]Yamano M, et al. Characteristics of inhibitory effects of serotonin (5-HT) 3-receptor antagonists, YM060 and YM114 (KAE-393), on the von Bezold-Jarisch reflex induced by 2-Methyl-5-HT, veratridine and electrical stimulation of vagus nerves in anesthetized rats. Jpn J Pharmacol. 1995 Dec;69 (4) :351-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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