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Galloflavin

CAT: 0804-HY-W040118-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W040118-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Galloflavin is a potent lactate dehydrogenase (LDH) inhibitor. The calculated Kis for pyruvate are 5.46 μM (LDH-A) and 15.06 μM (LDH-B) . Galloflavin hinders the proliferation of cancer cells by blocking glycolysis and ATP production[1][2].
CAS Number
568-80-9
UNSPSC
12352005
Hazard Statement
H302
Target
Lactate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/galloflavin.html
Concentration
10mM
Purity
99.36
Solubility
DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(OC(C=C1O)=C2OC1=O)C3=C2C(O)=C(O)C(O)=C3
Molecular Formula
C12H6O8
Molecular Weight
278.17
Precautions
H302
References & Citations
[1]Manerba M, Vettraino M, Fiume L, et al. Galloflavin (CAS 568-80-9) : a novel inhibitor of lactate dehydrogenase. ChemMedChem. 2012;7 (2) :311-317. |[2]Farabegoli F, et al. Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways. Eur J Pharm Sci. 2012;47 (4) :729-738. |[3]Han X, et al. Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells. J Hematol Oncol. 2015;8:2. Published 2015 Jan 29.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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