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Lintitript

CAT: 0804-HY-101764-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101764-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lintitript (SR 27897) is a highly potent, selective, orally active, competitive and non-peptide cholecystokinin (CCK1) receptor antagonist with an EC50 of 6 nM and a Ki of 0.2 nM. Lintitript displays > 33-fold selectivity more selective for CCK1 than CCK2 receptors (EC50 value of 200 nM) . Lintitript increases plasma concentration of leptin and food intake as well as plasma concentration of insulin[1][2][3].
CAS Number
136381-85-6
Product Name Alternative
SR 27897
UNSPSC
12352005
Hazard Statement
H301, H318
Target
Cholecystokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lintitript.html
Purity
99.58
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)CN1C(C(NC2=NC(C3=CC=CC=C3Cl)=CS2)=O)=CC4=C1C=CC=C4
Molecular Formula
C20H14ClN3O3S
Molecular Weight
411.86
Precautions
H301, H318
References & Citations
[1]Gully D, et al. Peripheral biological activity of SR 27897: a new potent non-peptide antagonist of CCKA receptors. Eur J Pharmacol. 1993 Feb 23;232 (1) :13-9.|[2]Gouldson P, et al. Contrasting roles of leu (356) in the human CCK (1) receptor for antagonist SR 27897 and agonist SR 146131 binding. Eur J Pharmacol. 1999 Nov 3;383 (3) :339-46.|[3]Cano V, et al. Regulation of leptin distribution between plasma and cerebrospinal fluid by cholecystokinin receptors. Br J Pharmacol. 2003 Oct;140 (4) :647-52.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
CCKAR

Alternative Products

CatalogName
BUP16244-01Lintitript

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