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GK13S

CAT: 0804-HY-153627-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-153627-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
G13KS is a deubiquitinase UCHL1 ligand and inhibitor. G13KS inhibits recombinant and cellular UCHL1. G13KS reduces levels of monoubiquitin in human glioblastoma cells[1]. GK13S is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
UNSPSC
12352005
Target
Deubiquitinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gk13s.html
Purity
98.0
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NCCCC#C)C1=CC=C(N2C=C(NC([C@H]3CCN(C#N)C3)=O)N=C2)C=C1
Molecular Formula
C21H22N6O2
Molecular Weight
390.44
References & Citations
[1]Grethe C, et al. Structural basis for specific inhibition of the deubiquitinase UCHL1. Nat Commun. 2022 Oct 10;13 (1) :5950.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
UCHL1

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