GLP-26

• Description:

  GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools[1]. GLP-26 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC:

  12352005

• Target:

  HBV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/glp-26.html

• Purity:

  98.36

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  O=C (C1=C (C) C (C (C (NCC#C) =O) =O) =C (C) N1C) NC2=CC=C (F) C (F) =C2

• Molecular Formula:

  C19H17F2N3O3

• Molecular Weight:

  373.35

• References & Citations:

  [1]Nijampatnam B, et al. Recent advances in the development of HBV capsid assembly modulators. Curr Opin Chem Biol. 2019 Jun;50:73-79.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2133017-36-2